Etsy: http://www.etsy.com/
A great place to buy a gift for nearly everyone, for anything and for every budget. They have jewelry, clothing and other really random homemade things. And to make you feel better you are supporting smaller artists.
Pros:
-Wide selection of everything and at different price points
-Unique work
-Great prices for some really great artwork
Cons:
-Beware! make sure you read the sellers description carefully, don't be afraid to ask them questions and read customer reviews. You might get unlucky and buy from a subpar crafter.
Magazine subscription
I have to admit I stole this idea from a friend who got this for my birthday. I thought it was a great idea, and every month I kept getting new things to read. Some magazine ideas could be Print, ID, CMYK, DWELL
Pros:
-So many niche magazines you can really get one that fits their interests
-They are reminded of your gift when a new one comes in the mail every month
Cons:
-Can be expensive
-Subscribe in advance so they get it by their birthday
Veer: http://www.veer.com/
You can buy some really neat designer gifts from clothing to wall decorations. Veer just updated their website and now have a credits, prepaid, option available
Pros:
-Get some designer-esk fashion
Cons:
-Many of the items range from medium to high in price
Book
Designers love looking at things for inspiration, so why not get them a designer book?
Pros:
-Inspirational
-So many books, there is bound to be one to fit the person you are shopping for
Cons:
-Many books can be quite expensive
Art supplies
Why not buy them a sketchbook, or a really nice drawing pen?
Pros:
-Give them what they need and not just a fluff gift
Cons:
-You need to know specifically what kind of materials they use
Threadless: http://www.threadless.com/
Why not get them something original, while supporting smaller artists.
Pros:
-Original, you cant buy it in stores.
-You can get some really good deals, sometimes.
-New designs everyday
Cons:
-You need to know the size of the person you are buying for.